Early detection of wildlife disease pathogens using CRISPR-Cas system methods
The CRISPR Journal
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Abstract
Wildlife diseases are a considerable threat to human health, conservation, and the economy. Surveillance is a critical component to mitigate the impact of animal diseases in these sectors. To monitor human diseases, CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR-associated protein) biosensors have proven instrumental as diagnostic tools capable of detecting unique DNA and RNA sequences related to their associated pathogens. However, despite the significant advances in the general development of CRISPR-Cas biosensors, their use to support wildlife disease management is lagging. In some cases, wildlife diseases of concern could be rapidly surveyed using these tools with minimal technical, operational, or cost requirements to end users. This review explores the potential to further leverage this technology to advance wildlife disease monitoring and highlights how concerted standardization of protocols can help to ensure data reliability.
| Publication type | Article |
|---|---|
| Publication Subtype | Journal Article |
| Title | Early detection of wildlife disease pathogens using CRISPR-Cas system methods |
| Series title | The CRISPR Journal |
| DOI | 10.1089/crispr.2024.0030 |
| Edition | Online First |
| Year Published | 2024 |
| Language | English |
| Publisher | Mary Ann Liebert, Inc. |
| Contributing office(s) | Office of the AD Ecosystems, Wetland and Aquatic Research Center |
| Google Analytic Metrics | Metrics page |